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Raman-guided analysis of drug response combined with chemometrics helps monitor the effect of ruxolitinib on acute lymphoblastic leukemia.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy - 5 Jun 2026

Adamczyk Adriana, Jakubowska Justyna, Szewczyk Marta, Nowakowska Anna M, Stawoski Kacper, Pastorczak Agata, Młynarski Wojciech, Baranska Małgorzata, Ostrowska Kinga, Majzner Katarzyna

Abstract excerpt

Ruxolitinib (RUX), a selective JAK1/JAK2 inhibitor, is considered a therapeutic option for childhood B-cell precursor acute lymphoblastic leukemia (B-ALL) with JAK2 gain-of-function mutations. This study aimed to evaluate whether Raman spectroscopy combined with chemometric analysis can monitor the biochemical effects of RUX treatment in B-ALL cell lines. We employed single-cell confocal Raman imaging, flow...

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PMID: 41762803
DOI: 10.1016/j.saa.2026.127566

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JAK2
JAK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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