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Article

Imaging vs Nonimaging Raman Spectroscopy for High-Throughput Single-Cell Phenotyping.

Analytical chemistry - 7 May 2024

Hobro Alison J, Pavillon Nicolas, Koike Kota, Sugiyama Takeshi, Umakoshi Takayuki, Verma Prabhat, Fujita Katsumasa, Smith Nicholas I

Abstract excerpt

Raman spectroscopy can provide nonbiased single-cell analysis based on the endogenous ensemble of biomolecules, with alterations in cellular content indicative of cell state and disease. The measurements themselves can be performed in a variety of modes: generally, full imaging takes the most time but can provide the most information. By reducing the imaging resolution and generating the most characteristic...

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Identifiers

PMID: 38653469
DOI: 10.1021/acs.analchem.4c00236
PMCID: PMC11080993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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