Article
Short Communication: In Vitro Accumulation of Drug Resistance Mutations in Chimeric Infectious Clones Containing Subtype B or C Reverse Transcriptase and Selected with Tenofovir or Didanosine.
AIDS research and human retroviruses - 1 Aug 2015
Cunha Rodrigo D, Abreu Celina M, Sousa Arielly K P, Mabombo Viviana C J, Nijhuis Monique, de Jong Dorien, Tanuri Amilcar
Abstract excerpt
Highly active antiretroviral therapy (HAART) contributed to the improvement in the life expectancy of HIV-infected patients. However, the emergence of drug-resistant mutations (DRM) is a major viral factor impacting therapeutic failure. Differences in DRM can occur among HIV-1 subtypes. We evaluate the kinetics of the selection of resistance mutations in vitro analyzing two chimeric clones that contain the...
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