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Article

Differential in vitro kinetics of drug resistance mutation acquisition in HIV-1 RT of subtypes B and C.

PloS one - 1 Jan 2012

Cunha Rodrigo D, Abreu Celina M, Gonzalez Luis M F, Nijhuis Monique, de Jong Dorien, Aguiar Renato S, Afonso Adriana O, Brindeiro Rodrigo M, Tanuri Amilcar

Abstract excerpt

BACKGROUND: HIV-1 subtype B is the most prevalent in developed countries and, consequently, it has been extensively studied. On the other hand, subtype C is the most prevalent worldwide and therefore is a reasonable target for future studies. Here we evaluate the acquisition of resistance and the viability of HIV-1 subtype B and C RT clones from different isolates that were subjected to in vitro selection...

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Identifiers

PMID: 23056372
DOI: 10.1371/journal.pone.0046622
PMCID: PMC3463560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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