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Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosis

10 Jun 2016

Abstract excerpt

There is an urgent need to identify new treatments for tuberculosis (TB), a major infectious disease caused by Mycobacterium tuberculosis (Mtb), which results in 1.5 million deaths each year. We have targeted two essential enzymes in this organism that are promising for antibacterial therapy and reported to be inhibited by naphthoquinones. ThyX is an essential thymidylate synthase that is mechanistically and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27283217
DOI: 10.1038/srep27792

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