DNA topoisomerase I and DNA gyrase as targets for TB therapy

doi:10.1016/j.drudis.2016.11.006

Article

DNA topoisomerase I and DNA gyrase as targets for TB therapy

14 Nov 2016

Abstract excerpt

Tuberculosis (TB) is the deadliest bacterial disease in the world. New therapeutic agents are urgently needed to replace existing drugs for which resistance is a significant problem. DNA topoisomerases are well-validated targets for antimicrobial and anticancer chemotherapies. Although bacterial topoisomerase I has yet to be exploited as a target for clinical antibiotics, DNA gyrase has been extensively targeted,...

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