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Article

p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus.

The Journal of biological chemistry - 26 Dec 2003

Yokoo Tomotaka, Toyoshima Hideo, Miura Mitsuhiro, Wang Yuhui, Iida Kaoruko Tada, Suzuki Hiroaki, Sone Hirohito, Shimano Hitoshi, Gotoda Takanari, Nishimori Shigeki, Tanaka Keiji, Yamada Nobuhiro

Abstract excerpt

p57Kip2 is the only cyclin-dependent kinase (Cdk) inhibitor shown to be essential for mouse embryogenesis. The fact suggests that p57 has a specific role that cannot be compensated by other Cdk inhibitors. LIM-kinase 1 (LIMK-1) is a downstream effector of the Rho family of GTPases that phosphoryl...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14530263
DOI: 10.1074/jbc.M309334200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14530263-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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