Article
Dysregulation of Rho GTPases in orofacial cleft patients-derived primary cells leads to impaired cell migration, a potential cause of cleft/lip palate development.
Cells & development - 1 Mar 2021
El-Sibai Mirvat, El Hajj Joelle, Al Haddad Maria, El Baba Nada, Al Saneh Mounir, Daoud Khatoun Wassim, Helaers Raphaël, Vikkula Miikka, El Atat Oula, Sabbagh Joseph, Abou Chebel Naji, Ghassibe-Sabbagh Michella
Abstract excerpt
Cleft lip and/or palate are a split in the lip, the palate or both. This results from the inability of lip buds and palatal shelves to properly migrate and assemble during embryogenesis. By extracting primary cells from a cleft patient, we aimed at offering a better understanding of the signaling mechanisms and interacting molecules involved in the lip and palate formation and fusion. With Rho GTPases being...
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