Article
Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant.
Cell death & disease - 11 Jun 2015
Slatter T L, Hung N, Bowie S, Campbell H, Rubio C, Speidel D, Wilson M, Baird M, Royds J A, Braithwaite A W
Abstract excerpt
Growing evidence suggests the Δ133p53α isoform may function as an oncogene. It is overexpressed in many tumors, stimulates pathways involved in tumor progression, and inhibits some activities of wild-type p53, including transactivation and apoptosis. We hypothesized that Δ133p53α would have an even more profound effect on p53 variants with weaker tumor-suppressor capability. We tested this using a mouse model...
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