Article
A purine nucleotide biosynthesis enzyme guanosine monophosphate reductase is a suppressor of melanoma invasion.
Cell reports - 31 Oct 2013
Wawrzyniak Joseph A, Bianchi-Smiraglia Anna, Bshara Wiam, Mannava Sudha, Ackroyd Jeff, Bagati Archis, Omilian Angela R, Im Michael, Fedtsova Natalia, Miecznikowski Jeffrey C, Moparthy Kalyana C, Zucker Shoshanna N, Zhu Qianqian, Kozlova Nadezhda I, Berman Albert E, Hoek Keith S, Gudkov Andrei V, Shewach Donna S, Morrison Carl D, Nikiforov Mikhail A
Abstract excerpt
Melanoma is one of the most aggressive types of human cancers, and the mechanisms underlying melanoma invasive phenotype are not completely understood. Here, we report that expression of guanosine monophosphate reductase (GMPR), an enzyme involved in de novo biosynthesis of purine nucleotides, was downregulated in the invasive stages of human melanoma. Loss- and gain-of-function experiments revealed that GMPR...
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