Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sensitization of Glioblastoma Cells to Irradiation by Modulating the Glucose Metabolism.

Molecular cancer therapeutics - 1 Aug 2015

Shen Han, Hau Eric, Joshi Swapna, Dilda Pierre J, McDonald Kerrie L

Abstract excerpt

Because radiotherapy significantly increases median survival in patients with glioblastoma, the modulation of radiation resistance is of significant interest. High glycolytic states of tumor cells are known to correlate strongly with radioresistance; thus, the concept of metabolic targeting needs to be investigated in combination with radiotherapy. Metabolically, the elevated glycolysis in glioblastoma cells was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Oxidative Phosphorylation
Share to Carbohydrate Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Cycle Checkpoints

Share to Glioblastoma

Share to Glycolysis

Share to Radiation Tolerance

Share to Radiotherapy

Share to Xenograft Model Antitumor Assays

Source

Identifiers

PMID: 26063767
DOI: 10.1158/1535-7163.MCT-15-0247

Genes

PDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sensitization of Glioblastoma Cells to Irradiation by Modulating the Glucose Metabolism.PMID 26063767Read ↗

Beyond the Warburg Effect: Oxidative and Glycolytic Phenotypes Coexist within the Metabolic Heterogeneity of Glioblastoma.Semantic proximity Read ↗

M2 isoform of pyruvate kinase rewires glucose metabolism during radiation therapy to promote an antioxidant response and glioblastoma radioresistanceSemantic proximity Read ↗

Metabolism and signaling crosstalk in glioblastoma progression and therapy resistanceSemantic proximity Read ↗

Glucose addiction in cancer therapy: advances and drawbacksSemantic proximity Read ↗

The roles of glucose metabolic reprogramming in chemo- and radio-resistanceSemantic proximity Read ↗

MYC Expression and Metabolic Redox Changes in Cancer Cells: A Synergy Able to Induce ChemoresistanceSemantic proximity Read ↗

Feedback loop between hypoxia and energy metabolic reprogramming aggravates the radioresistance of cancer cellsSemantic proximity Read ↗

Tumor metabolism: new opportunities for cancer therapy.Semantic proximity Read ↗

Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose MetabolismSemantic proximity Read ↗

Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance.Semantic proximity Read ↗

Pyruvate dehydrogenase kinase expression profile is a biomarker for cancer sensitivity to dichloroacetate-mediated growth inhibitionSemantic proximity Read ↗

Effect of glycolysis inhibition by miR-448 on glioma radiosensitivitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.