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Feedback loop between hypoxia and energy metabolic reprogramming aggravates the radioresistance of cancer cells

22 May 2024

Abstract excerpt

Radiotherapy is one of the mainstream approaches for cancer treatment, although the clinical outcomes are limited due to the radioresistance of tumor cells. Hypoxia and metabolic reprogramming are the hallmarks of tumor initiation and progression and are closely linked to radioresistance. Inside a tumor, the rate of angiogenesis lags behind cell proliferation, and the underdevelopment and abnormal functions of...

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PMID: 38778409
DOI: 10.1186/s40164-024-00519-1

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