Article
Musculoskeletal integration at the wrist underlies the modular development of limb tendons.
Development (Cambridge, England) - 15 Jul 2015
Huang Alice H, Riordan Timothy J, Pryce Brian, Weibel Jennifer L, Watson Spencer S, Long Fanxin, Lefebvre Veronique, Harfe Brian D, Stadler H Scott, Akiyama Haruhiko, Tufa Sara F, Keene Douglas R, Schweitzer Ronen
Abstract excerpt
The long tendons of the limb extend from muscles that reside in the zeugopod (arm/leg) to their skeletal insertions in the autopod (paw). How these connections are established along the length of the limb remains unknown. Here, we show that mouse limb tendons are formed in modular units that combine to form a functional contiguous structure; in muscle-less limbs, tendons develop in the autopod but do not extend...
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