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Article

Hox11 genes establish synovial joint organization and phylogenetic characteristics in developing mouse zeugopod skeletal elements.

Development (Cambridge, England) - 1 Nov 2010

Koyama Eiki, Yasuda Tadashi, Minugh-Purvis Nancy, Kinumatsu Takashi, Yallowitz Alisha R, Wellik Deneen M, Pacifici Maurizio

Abstract excerpt

Hox11 genes are essential for zeugopod skeletal element development but their roles in synovial joint formation remain largely unknown. Here, we show that the elbow and knee joints of mouse embryos lacking all Hox11 paralogous genes are specifically remodeled and reorganized. The proximal ends of...

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Identifiers

PMID: 20978074
DOI: 10.1242/dev.053447
PMCID: PMC3049277

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20978074-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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