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Article

Structural integrity of the ribonuclease H domain in HIV-1 reverse transcriptase.

Proteins - 1 Aug 2015

Slack Ryan L, Spiriti Justin, Ahn Jinwoo, Parniak Michael A, Zuckerman Daniel M, Ishima Rieko

Abstract excerpt

The mature form of reverse transcriptase (RT) is a heterodimer comprising the intact 66-kDa subunit (p66) and a smaller 51-kDa subunit (p51) that is generated by removal of most of the RNase H (RNH) domain from a p66 subunit by proteolytic cleavage between residues 440 and 441. Viral infectivity is eliminated by mutations such as F440A and E438N in the proteolytic cleavage sequence, while normal processing and...

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Identifiers

PMID: 26061827
DOI: 10.1002/prot.24843
PMCID: PMC4509971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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