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Article

Highly conserved glycine 86 and arginine 87 residues contribute differently to the structure and activity of the mature HIV-1 protease.

Proteins - 1 Mar 2010

Ishima Rieko, Gong Qingguo, Tie Yunfeng, Weber Irene T, Louis John M

Abstract excerpt

The structural and functional role of conserved residue G86 in HIV-1 protease (PR) was investigated by NMR and crystallographic analyses of substitution mutations of glycine to alanine and serine (PR(G86A) and PR(G86S)). While PR(G86S) had undetectable catalytic activity, PR(G86A) exhibited approximately 6000-fold lower catalytic activity than PR. (1)H-(15)N NMR correlation spectra revealed that PR(G86A) and...

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Identifiers

PMID: 19899162
DOI: 10.1002/prot.22625
PMCID: PMC2811763

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Source receipt: pubmed, retrieved 7 Sept 2026.

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