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Article

Mutational and structural studies aimed at characterizing the monomer of HIV-1 protease and its precursor.

The Journal of biological chemistry - 8 Jun 2007

Ishima Rieko, Torchia Dennis A, Louis John M

Abstract excerpt

An experimental protocol for folding the mature human immunodeficiency virus-1 (HIV-1) protease is presented that facilitates NMR studies at a low protein concentration of approximately 20 micoM. Under these conditions, NMR spectra show that the mature protease lacking its terminal beta-sheet residues 1-4 and 96-99 (PR(5-95)) exhibits a stable monomer fold spanning the region 10-90 that is similar to that of the...

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Identifiers

PMID: 17412697
DOI: 10.1074/jbc.M701304200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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