Article
Mammalian target of rapamycin signaling inhibition ameliorates vascular calcification via Klotho upregulation.
Kidney international - 1 Oct 2015
Zhao Yang, Zhao Ming-Ming, Cai Yan, Zheng Ming-Fei, Sun Wei-Liang, Zhang Song-Yang, Kong Wei, Gu Jun, Wang Xian, Xu Ming-Jiang
Abstract excerpt
Vascular calcification (VC) is a major risk factor for cardiovascular mortality in chronic renal failure (CRF) patients, but the pathogenesis remains partially unknown and effective therapeutic targets should be urgently explored. Here we pursued the therapeutic role of rapamycin in CRF-related VC. Mammalian target of rapamycin (mTOR) signal was activated in the aortic wall of CRF rats. As expected, oral...
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