Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intermedin1-53 attenuates vascular calcification in rats with chronic kidney disease by upregulation of α-Klotho.

Kidney international - 1 Mar 2016

Chang Jin Rui, Guo Jun, Wang Yue, Hou Yue Long, Lu Wei Wei, Zhang Jin Sheng, Yu Yan Rong, Xu Ming Jiang, Liu Xiu Ying, Wang Xiu Jie, Guan You Fei, Zhu Yi, Du Jie, Tang Chao Shu, Qi Yong Fen

Abstract excerpt

Deficiency in α-Klotho is involved in the pathogenesis of vascular calcification. Since intermedin (IMD)1-53 (a calcitonin/calcitonin gene-related peptide) protects against vascular calcification, we studied whether IMD1-53 inhibits vascular calcification by upregulating α-Klotho. A rat model of chronic kidney disease (CKD) with vascular calcification induced by the 5/6 nephrectomy plus vitamin D3 was used for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aorta, Thoracic
Share to Cell Transdifferentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholecalciferol

Share to Klotho Proteins

Share to Nephrectomy

Share to Peptide Hormones

Share to Receptors, Calcitonin

Share to Vascular Calcification

Source

Identifiers

PMID: 26880455
DOI: 10.1016/j.kint.2015.12.029

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intermedin1-53 attenuates vascular calcification in rats with chronic kidney disease by upregulation of α-Klotho.PMID 26880455Read ↗

Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein.Semantic proximity Read ↗

Vascular calcification in CKD: New insights into its mechanismsSemantic proximity Read ↗

Key regulators of vascular calcification in chronic kidney disease: Hyperphosphatemia, BMP2, and RUNX2Semantic proximity Read ↗

Vascular calcification and osteoporosis--from clinical observation towards molecular understanding.Semantic proximity Read ↗

Mammalian target of rapamycin signaling inhibition ameliorates vascular calcification via Klotho upregulation.Semantic proximity Read ↗

High calcium, phosphate and calcitriol supplementation leads to an osteocyte-like phenotype in calcified vessels and bone mineralisation defect in uremic rats.Semantic proximity Read ↗

Restoration of microRNA‐30b expression alleviates vascular calcification through the mTOR signaling pathway and autophagySemantic proximity Read ↗

Visfatin from Adipocyte Accelerates Vascular Calcification via TLR4Semantic proximity Read ↗

Fibroblast growth factor 21; review on its participation in vascular calcification pathology.Semantic proximity Read ↗

alpha-Klotho: a regulator that integrates calcium homeostasis.Semantic proximity Read ↗

Augmentation of phosphate-induced osteo-/chondrogenic transformation of vascular smooth muscle cells by homoarginine.Semantic proximity Read ↗

Circulating uromodulin inhibits vascular calcification by interfering with pro-inflammatory cytokine signalling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.