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Article

Engineering of Immunoglobulin Fc Heterodimers Using Yeast Surface-Displayed Combinatorial Fc Library Screening.

PloS one - 1 Jan 2015

Choi Hye-Ji, Kim Ye-Jin, Choi Dong-Ki, Kim Yong-Sung

Abstract excerpt

Immunoglobulin Fc heterodimers, which are useful scaffolds for the generation of bispecific antibodies, have been mostly generated through structure-based rational design methods that introduce asymmetric mutations into the CH3 homodimeric interface to favor heterodimeric Fc formation. Here, we report an approach to generate heterodimeric Fc variants through directed evolution combined with yeast surface display....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26675656
DOI: 10.1371/journal.pone.0145349
PMCID: PMC4682967

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