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Article

Mutation Analysis of the RAD51C and RAD51D Genes in High-Risk Ovarian Cancer Patients and Families from the Czech Republic.

PloS one - 1 Jan 2015

Janatova Marketa, Soukupova Jana, Stribrna Jana, Kleiblova Petra, Vocka Michal, Boudova Petra, Kleibl Zdenek, Pohlreich Petr

Abstract excerpt

Recent studies have conferred that the RAD51C and RAD51D genes, which code for the essential proteins involved in homologous recombination, are ovarian cancer (OC) susceptibility genes that may explain genetic risks in high-risk patients. We performed a mutation analysis in 171 high-risk BRCA1 and BRCA2 negative OC patients, to evaluate the frequency of hereditary RAD51C and RAD51D variants in Czech population....

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Source

Open in PubMed Open full text

Identifiers

PMID: 26057125
DOI: 10.1371/journal.pone.0127711
PMCID: PMC4461297

Genes

BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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