Article
Gene expression of glutamate transporters SLC1A1, SLC1A3 and SLC1A6 in the cerebellar subregions of elderly schizophrenia patients and effects of antipsychotic treatment.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Sept 2013
Wilmsdorff Martina Von, Blaich Carolin, Zink Mathias, Treutlein Jens, Bauer Manfred, Schulze Thomas, Schneider-Axmann Thomas, Gruber Oliver, Rietschel Marcella, Schmitt Andrea, Falkai Peter
Abstract excerpt
OBJECTIVES: The glutamatergic hypothesis of schizophrenia proposes alterations of excitatory amino acid transporters (solute carrier family, SLCs) expression and cerebellar dysfunctions. The influence of the neuregulin-1 (NRG1) risk genotype or effects of antipsychotics on expression of EAATs are unknown. METHODS: We compared post-mortem samples from the cerebellar hemispheres and vermis of 10 schizophrenia...
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