Article
Specification of receptor-binding phenotypes of influenza virus isolates from different hosts using synthetic sialylglycopolymers: non-egg-adapted human H1 and H3 influenza A and influenza B viruses share a common high binding affinity for 6'-sialyl(N-acetyllactosamine).
Virology - 9 Jun 1997
Gambaryan A S, Tuzikov A B, Piskarev V E, Yamnikova S S, Lvov D K, Robertson J S, Bovin N V, Matrosovich M N
Abstract excerpt
Synthetic sialylglycoconjugates bearing 3'-sialyllactose, 6'-sialyllactose, or 6'-sialyl(N-acetyllactosamine) moieties attached to the polyacrylic acid carrier (P-3-SL, P-6-SL, and P-6-SLN, respectively) were prepared and tested for their ability to bind to influenza virus isolates from different hosts in a competitive solid phase assay. The virus panel included egg-grown avian and porcine strains, as well as...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.