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Immune Escape Adaptive Mutations in Hemagglutinin Are Responsible for the Antigenic Drift of Eurasian Avian-Like H1N1 Swine Influenza Viruses.

Journal of virology - 24 Aug 2022

Xu Chengzhi, Zhang Naixin, Yang Yuying, Liang Wenhua, Zhang Yaping, Wang Jingfei, Suzuki Yasuo, Wu Yunpu, Chen Yan, Yang Huanliang, Qiao Chuanling, Chen Hualan

Abstract excerpt

The continuous antigenic variation of influenza A viruses remains a major hurdle for vaccine selection; however, the molecular determinants and mechanisms of antigenic change remain largely unknown. In this study, two escape mutants were generated by serial passages of the Eurasian avian-like H1N1 swine influenza virus (EA H1N1 SIV) A/swine/Henan/11/2005 (HeN11) in the presence of two neutralizing monoclonal...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Hemagglutinin Glycoproteins, Influenza Virus

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Identifiers

PMID: 35916512
DOI: 10.1128/jvi.00971-22
PMCID: PMC9400474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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