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Glyco-engineered MDCK cells display preferred receptors of H3N2 influenza absent in eggs used for vaccines

4 Oct 2023

Abstract excerpt

Evolution of human H3N2 influenza viruses driven by immune selection has narrowed the receptor specificity of the hemagglutinin (HA) to a restricted subset of human-type (Neu5Acα2-6 Gal) glycan receptors that have extended poly-LacNAc (Galβ1-4GlcNAc) repeats. This altered specificity has presented challenges for hemagglutination assays, growth in laboratory hosts, and vaccine production in eggs. To assess the...

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PMID: 37794004
DOI: 10.1038/s41467-023-41908-0

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