Article
New mutations in chronic lymphocytic leukemia identified by target enrichment and deep sequencing.
PloS one - 1 Jan 2012
Doménech Elena, Gómez-López Gonzalo, Gzlez-Peña Daniel, López Mar, Herreros Beatriz, Menezes Juliane, Gómez-Lozano Natalia, Carro Angel, Graña Osvaldo, Pisano David G, Domínguez Orlando, García-Marco José A, Piris Miguel A, Sánchez-Beato Margarita
Abstract excerpt
Chronic lymphocytic leukemia (CLL) is a heterogeneous disease without a well-defined genetic alteration responsible for the onset of the disease. Several lines of evidence coincide in identifying stimulatory and growth signals delivered by B-cell receptor (BCR), and co-receptors together with NFkB pathway, as being the driving force in B-cell survival in CLL. However, the molecular mechanism responsible for this...
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