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Article

Pervasive Genotypic Mosaicism in Founder Mice Derived from Genome Editing through Pronuclear Injection.

PloS one - 1 Jan 2015

Oliver Daniel, Yuan Shuiqiao, McSwiggin Hayden, Yan Wei

Abstract excerpt

Genome editing technologies, especially the Cas9/CRISPR system, have revolutionized biomedical research over the past several years. Generation of novel alleles has been simplified to unprecedented levels, allowing for rapid expansion of available genetic tool kits for researchers. However, the issue of genotypic mosaicism has become evident, making stringent analyses of the penetrance of genome-edited alleles...

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Share to CRISPR-Cas Systems
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26053263
DOI: 10.1371/journal.pone.0129457
PMCID: PMC4459985

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