Article
Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis.
PLoS genetics - 1 Sept 2018
Hendricks William P D, Zismann Victoria, Sivaprakasam Karthigayini, Legendre Christophe, Poorman Kelsey, Tembe Waibhav, Perdigones Nieves, Kiefer Jeffrey, Liang Winnie, DeLuca Valerie, Stark Mitchell, Ruhe Alison, Froman Roe, Duesbery Nicholas S, Washington Megan, Aldrich Jessica, Neff Mark W, Huentelman Matthew J, Hayward Nicholas, Brown Kevin, Thamm Douglas, Post Gerald, Khanna Chand, Davis Barbara, Breen Matthew, Sekulic Alexander, Trent Jeffrey M
Abstract excerpt
Canine malignant melanoma, a significant cause of mortality in domestic dogs, is a powerful comparative model for human melanoma, but little is known about its genetic etiology. We mapped the genomic landscape of canine melanoma through multi-platform analysis of 37 tumors (31 mucosal, 3 acral, 2 cutaneous, and 1 uveal) and 17 matching constitutional samples including long- and short-insert whole genome...
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