Article
Risk Factors Associated with Colorectal Cancer in a Subset of Patients with Mutations in MLH1 and MSH2 in Taiwan Fulfilling the Amsterdam II Criteria for Lynch Syndrome.
PloS one - 1 Jan 2015
Kamiza Abram Bunya, Hsieh Ling-Ling, Tang Reiping, Chien Huei-Tzu, Lai Chih-Hsiung, Chiu Li-Ling, Lo Tsai-Ping, Hung Kuan-Yi, Wang Chun-Yi, You Jeng-Fu, Hsiung Chao A, Yeh Chih-Ching
Abstract excerpt
BACKGROUND AND AIM: Lynch syndrome, caused by germline mutations in mismatch repair genes, is a predisposing factor for colorectal cancer (CRC). This retrospective cohort study investigated the risk factors associated with the development of CRC in patients with MLH1 and MSH2 germline mutations. METHODS: In total, 301 MLH1 and MSH2 germline mutation carriers were identified from the Amsterdam criteria family...
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