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Article

Changes in Adeno-Associated Virus-Mediated Gene Delivery in Retinal Degeneration

18 Dec 2009

Abstract excerpt

Gene therapies for retinal degeneration have relied on subretinal delivery of viral vectors carrying therapeutic DNA. The subretinal injection is clearly not ideal as it limits the viral transduction profile to a focal region at the injection site and negatively affects the neural retina by detaching it from the supportive retinal pigment epithelium (RPE). We assessed changes in adeno-associated virus (AAV)...

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PMID: 20021232
DOI: 10.1089/hum.2009.194

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