Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transduction optimization of AAV vectors for human gene therapy of glaucoma and their reversed cell entry characteristics

14 Oct 2019

Abstract excerpt

The trabecular meshwork (TM) of the eye is responsible for maintaining physiological intraocular pressure (IOP). Dysfunction of this tissue results in elevated IOP, subsequent optic nerve damage and glaucoma, the world's leading cause of irreversible blindness. IOP regulation by delivering candidate TM genes would offer an enormous clinical advantage to the current daily-drops/surgery treatment. Initially, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glaucoma and retinal disorders
Share to Retinal Development and Disorders
Share to Retinopathy of Prematurity Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31611639
DOI: 10.1038/s41434-019-0105-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transduction optimization of AAV vectors for human gene therapy of glaucoma and their reversed cell entry characteristicsPMID 31611639Read ↗

Mechanisms of AAV transduction in glaucoma‐associated human trabecular meshwork cellsSemantic proximity Read ↗

Capsid Mutated Adeno-Associated Virus Delivered to the Anterior Chamber Results in Efficient Transduction of Trabecular Meshwork in Mouse and Rat.Semantic proximity Read ↗

Adeno-associated virus vectors for retinal gene therapy in basic research and clinical studiesSemantic proximity Read ↗

An adeno-associated virus variant enabling efficient ocular-directed gene delivery across speciesSemantic proximity Read ↗

Long-Term, Targeted Genetic Modification of the Aqueous Humor Outflow Tract Coupled with Noninvasive Imaging of Gene Expression In VivoSemantic proximity Read ↗

Identification of AAV Capsids with Enhanced Intravitreal Transduction and Favorable Safety Profile in Non-Human PrimatesSemantic proximity Read ↗

The concept of gene therapy for glaucomaSemantic proximity Read ↗

Retinal transduction profiling of diverse AAV serotypes via intravitreal injectionSemantic proximity Read ↗

Quantitative single-cell transcriptome-based ranking of engineered AAVs in human retinal explantsSemantic proximity Read ↗

Cellular and Tissue Selectivity of AAV Serotypes for Gene Delivery to Chondrocytes and CartilageSemantic proximity Read ↗

Novel AAV serotypes for improved ocular gene transferSemantic proximity Read ↗

Ocular Gene Therapy: An Overview of Viral Vectors, Immune Responses, and Future DirectionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.