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Article

A human leukocyte antigen locus haplotype confers risk for allopurinol-related adverse effects in Caucasian patients with gout.

Pharmacogenetics and genomics - 1 Aug 2015

Roberts Rebecca L, Wallace Mary C, Harrison Andrew, Dalbeth Nicola, Merriman Tony R, Stamp Lisa K

Abstract excerpt

A human leukocyte antigen haplotype comprising six single-nucleotide polymorphisms (SNPs) confers risk for allopurinol hypersensitivity syndrome in Caucasians. The objective of the current study was to test for association of this haplotype with other, less severe adverse effects (AEs) of allopurinol therapy in a large New Zealand gout cohort. A total of 626 Caucasian and 766 Polynesian patients were genotyped...

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Identifiers

PMID: 26049586
DOI: 10.1097/FPC.0000000000000147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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