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Helicobacter pylorivirulence factors affecting gastric proton pump expression and acid secretion

5 Jun 2015

Abstract excerpt

Acute Helicobacter pylori infection of gastric epithelial cells and human gastric biopsies represses H,K-ATPase α subunit (HKα) gene expression and inhibits acid secretion, causing transient hypochlorhydria and supporting gastric H. pylori colonization. Infection by H. pylori strains deficient in the cag pathogenicity island (cag PAI) genes cagL, cagE, or cagM, which do not transfer CagA into host cells or induce...

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PMID: 26045613
DOI: 10.1152/ajpgi.00099.2015

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