Article
A Bayesian Partitioning Model for the Detection of Multilocus Effects in Case-Control Studies.
Human heredity - 1 Jan 2015
Ray Debashree, Li Xiang, Pan Wei, Pankow James S, Basu Saonli
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWASs) have identified hundreds of genetic variants associated with complex diseases, but these variants appear to explain very little of the disease heritability. The typical single-locus association analysis in a GWAS fails to detect variants with small effect sizes and to capture higher-order interaction among these variants. Multilocus association analysis provides...
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