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Article

Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150

30 Jun 2017

Abstract excerpt

Herpesviruses possess a genome-pressurized capsid. The 235-kilobase genome of human cytomegalovirus (HCMV) is by far the largest of any herpesvirus, yet it has been unclear how its capsid, which is similar in size to those of other herpesviruses, is stabilized. Here we report a HCMV atomic structure consisting of the herpesvirus-conserved capsid proteins MCP, Tri1, Tri2, and SCP and the HCMV-specific tegument...

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PMID: 28663444
DOI: 10.1126/science.aam6892

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