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Article

KRAS/NRAS/BRAF Mutations and Mismatch Repair Deficiency in Patients with Early-Onset Colorectal Cancer: A Clinicopathological Analysis.

International journal of surgical pathology - 1 Oct 2026

Liu Chao, Wang Yong

Abstract excerpt

BackgroundEarly-onset colorectal cancer (CRC) is characterized by distinct molecular and clinical features, a more advanced stage at diagnosis, and unique challenges in clinical management.AimThis study aimed to characterize the clinicopathologic features of early-onset CRC and investigate the associations between clinicopathologic characteristics and genetic mutations in young Chinese patients.MethodsIn total,...

Read the complete abstract on PubMed

Topics

Humans
Proto-Oncogene Proteins B-raf
Colorectal Neoplasms
Female
Adult
Proto-Oncogene Proteins p21(ras)

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

DNA Mismatch Repair

Male

Middle Aged

Mutation

Retrospective Studies

GTP Phosphohydrolases

Young Adult

Membrane Proteins

Age of Onset

DNA Mutational Analysis

Biomarkers, Tumor

Brain Neoplasms

Source

Identifiers

PMID: 42283096
DOI: 10.1177/10668969261457880

Genes

BRAF
KRAS
NRAS
MSH2
MSH6
PMS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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