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Article

Activation of Transient Receptor Potential Ankyrin-1 by Insoluble Particulate Material and Association with Asthma.

American journal of respiratory cell and molecular biology - 1 Dec 2015

Deering-Rice Cassandra E, Shapiro Darien, Romero Erin G, Stockmann Chris, Bevans Tatjana S, Phan Quang M, Stone Bryan L, Fassl Bernhard, Nkoy Flory, Uchida Derek A, Ward Robert M, Veranth John M, Reilly Christopher A

Abstract excerpt

Inhaled irritants activate transient receptor potential ankyrin-1 (TRPA1), resulting in cough, bronchoconstriction, and inflammation/edema. TRPA1 is also implicated in the pathogenesis of asthma. Our hypothesis was that particulate materials activate TRPA1 via a mechanism distinct from chemical agonists and that, in a cohort of children with asthma living in a location prone to high levels of air pollution,...

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Identifiers

PMID: 26039217
DOI: 10.1165/rcmb.2015-0086OC
PMCID: PMC4742944

Genes

TRPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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