Article
TRPA1 gene polymorphisms and childhood asthma.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Mar 2017
Gallo Valentina, Dijk F Nicole, Holloway John W, Ring Susan M, Koppelman Gerard H, Postma Dirkje S, Strachan David P, Granell Raquel, de Jongste Johan C, Jaddoe Vincent W V, den Dekker Herman T, Duijts Liesbeth, Henderson A John, Shaheen Seif O
Abstract excerpt
BACKGROUND: Animal data have suggested that the transient receptor potential ankyrin-1 (TRPA1) ion channel plays a key role in promoting airway inflammation in asthma and may mediate effects of paracetamol on asthma, yet confirmatory human data are lacking. To study associations of TRPA1 gene variants with childhood asthma and total IgE concentration, and interactions between TRPA1 and prenatal paracetamol...
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