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Article

Genomic Context of Azole Resistance Mutations in Aspergillus fumigatus Determined Using Whole-Genome Sequencing.

mBio - 2 Jun 2015

Abdolrasouli Alireza, Rhodes Johanna, Beale Mathew A, Hagen Ferry, Rogers Thomas R, Chowdhary Anuradha, Meis Jacques F, Armstrong-James Darius, Fisher Matthew C

Abstract excerpt

UNLABELLED: A rapid and global emergence of azole resistance has been observed in the pathogenic fungus Aspergillus fumigatus over the past decade. The dominant resistance mechanism appears to be of environmental origin and involves mutations in the cyp51A gene, which encodes a protein targeted by triazole antifungal drugs. Whole-genome sequencing (WGS) was performed for high-resolution single-nucleotide...

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Identifiers

PMID: 26037120
DOI: 10.1128/mBio.00536-15
PMCID: PMC4453006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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