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Article

Whole-genome comparison of Aspergillus fumigatus strains serially isolated from patients with aspergillosis.

Journal of clinical microbiology - 1 Dec 2014

Hagiwara Daisuke, Takahashi Hiroki, Watanabe Akira, Takahashi-Nakaguchi Azusa, Kawamoto Susumu, Kamei Katsuhiko, Gonoi Tohru

Abstract excerpt

The emergence of azole-resistant strains of Aspergillus fumigatus during treatment for aspergillosis occurs by a mutation selection process. Understanding how antifungal resistance mechanisms evolve in the host environment during infection is of great clinical importance and biological interest. Here, we used next-generation sequencing (NGS) to identify mutations that arose during infection by A. fumigatus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25232160
DOI: 10.1128/JCM.01105-14
PMCID: PMC4313286

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