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Article

Widely dispersed clonal expansion of multi-fungicide-resistant Aspergillus fumigatus limits genomic epidemiology prospects.

mBio - 11 Jun 2025

Snelders Eveline, Celia-Sanchez Brandi N, Nederlof Ymke C, Zhang Jianhua, Kortenbosch Hylke H, Zwaan Bas J, Tehupeiory-Kooreman Marlou, Giraldo-López Alejandra, van Dijk Karin, Wang Li, Brewer Marin T, Momany Michelle, Auxier Ben, Verweij Paul E

Abstract excerpt

Invasive aspergillosis, caused by Aspergillus fumigatus, represents a critical public health concern, particularly due to increasing resistance to triazole antifungals linked to TR34/TR46 cyp51A haplotypes. In our genomic epidemiology study of 157 A. fumigatus isolates from Dutch environmental hotspots and two clinical centers, we identified near-identical genomes in several environmental and patient isolates,...

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Identifiers

PMID: 40391955
DOI: 10.1128/mbio.03652-24
PMCID: PMC12153316

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