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Article

The conserved outer mitochondrial membrane protein Mtch regulates mitophagy during Drosophila intestinal development.

PLoS biology - 1 Jan 2026

Restrepo Lucas J, Graslie Jasmine K, Fortier Tina M, Baehrecke Eric H

Abstract excerpt

The clearance of mitochondria by autophagy (mitophagy) is important for cell health. Mutations in genes that are required for mitophagy, including Vps13D, PINK1, and Parkin, are associated with movement disorders, but gaps exist in our understanding of how Vps13D regulates mitophagy. Here, we identify Mtch (MTCH2 in humans) as a regulator of mitophagy based on a relationship with Vps13D during developmentally...

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Topics

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Share to Autophagy
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 41576035
DOI: 10.1371/journal.pbio.3003616
PMCID: PMC12829841

Genes

BNIP3
MTCH2
PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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