Article
Incompatibility between mitochondrial and nuclear genomes during oogenesis results in ovarian failure and embryonic lethality.
Development (Cambridge, England) - 1 Jul 2017
Zhang Chunyang, Montooth Kristi L, Calvi Brian R
Abstract excerpt
Mitochondrial dysfunction can cause female infertility. An important unresolved issue is the extent to which incompatibility between mitochondrial and nuclear genomes contributes to female infertility. It has previously been shown that a mitochondrial haplotype from D. simulans (simw501 ) is incompatible with a nuclear genome from the D. melanogaster strain Oregon-R (OreR), resulting in impaired development,...
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