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Article

Genetic analysis of Leishmania donovani tropism using a naturally attenuated cutaneous strain.

PLoS pathogens - 1 Jul 2014

Zhang Wen Wei, Ramasamy Gowthaman, McCall Laura-Isobel, Haydock Andrew, Ranasinghe Shalindra, Abeygunasekara Priyanka, Sirimanna Ganga, Wickremasinghe Renu, Myler Peter, Matlashewski Greg

Abstract excerpt

A central question in Leishmania research is why most species cause cutaneous infections but others cause fatal visceral disease. Interestingly, L. donovani causes both visceral and cutaneous leishmaniasis in Sri Lanka. L. donovani clinical isolates were therefore obtained from cutaneous leishmaniasis (CL-SL) and visceral leishmaniasis (VL-SL) patients from Sri Lanka. The CL-SL isolate was severely attenuated...

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Share to Gene Deletion
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 24992200
DOI: 10.1371/journal.ppat.1004244
PMCID: PMC4081786

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