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Sleeping Beauty System to Redirect T-cell Specificity for Human Applications

31 Jan 2013

Abstract excerpt

The Sleeping Beauty (SB) transposon/transposase DNA plasmid system is used to genetically modify cells for long-term transgene expression. We adapted the SB system for human application and generated T cells expressing a chimeric antigen receptor (CAR) specific for CD19. Electrotransfer of CD19-specific SB DNA plasmids in peripheral blood mononuclear cells and propagation on CD19 artificial antigen presenting...

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PMID: 23377665
DOI: 10.1097/cji.0b013e3182811ce9

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