A new approach to gene therapy using <i>Sleeping Beauty</i> to genetically modify clinical‐grade T cells to target <scp>CD</scp>19

Abstract excerpt

The advent of efficient approaches to the genetic modification of T cells has provided investigators with clinically appealing methods to improve the potency of tumor-specific clinical grade T cells. For example, gene therapy has been successfully used to enforce expression of chimeric antigen receptors (CARs) that provide T cells with ability to directly recognize tumor-associated antigens without the need for...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to CAR-T cell therapy research
• Share to Virus-based gene therapy research