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Article

Identification of epidermal growth factor receptor and its inhibitory microRNA141 as novel targets of Krüppel-like factor 8 in breast cancer.

Oncotarget - 28 Aug 2015

Li Tianshu, Lu Heng, Mukherjee Debarati, Lahiri Satadru K, Shen Chao, Yu Lin, Zhao Jihe

Abstract excerpt

Krüppel-like factor 8 (KLF8) is a dual transcriptional factor critical for breast cancer progression. Epidermal growth factor receptor (EGFR) is frequently overexpressed in aggressive such as triple-negative breast cancer and associated with poor clinical outcomes. Here we report a novel KLF8-EGFR signaling axis in breast cancer. We identified a highly correlated co-overexpression between KLF8 and EGFR in...

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Source

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Identifiers

PMID: 26025929
DOI: 10.18632/oncotarget.4077
PMCID: PMC4673276

Genes

EGFR
KLF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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