Article
Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion.
The American journal of pathology - 1 Jul 2012
Whitsett Timothy G, Cheng Emily, Inge Landon, Asrani Kaushal, Jameson Nathan M, Hostetter Galen, Weiss Glen J, Kingsley Christopher B, Loftus Joseph C, Bremner Ross, Tran Nhan L, Winkles Jeffrey A
Abstract excerpt
Lung cancer is the leading cause of cancer deaths worldwide; approximately 85% of these cancers are non-small cell lung cancer (NSCLC). Patients with NSCLC frequently have tumors harboring somatic mutations in the epidermal growth factor receptor (EGFR) gene that cause constitutive receptor activation. These patients have the best clinical response to EGFR tyrosine kinase inhibitors (TKIs). Herein, we show that...
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