Article
A risk prediction algorithm for ovarian cancer incorporating BRCA1, BRCA2, common alleles and other familial effects.
Journal of medical genetics - 1 Jul 2015
Jervis Sarah, Song Honglin, Lee Andrew, Dicks Ed, Harrington Patricia, Baynes Caroline, Manchanda Ranjit, Easton Douglas F, Jacobs Ian, Pharoah Paul P D, Antoniou Antonis C
Abstract excerpt
BACKGROUND: Although BRCA1 and BRCA2 mutations account for only ∼27% of the familial aggregation of ovarian cancer (OvC), no OvC risk prediction model currently exists that considers the effects of BRCA1, BRCA2 and other familial factors. Therefore, a currently unresolved problem in clinical genetics is how to counsel women with family history of OvC but no identifiable BRCA1/2 mutations. METHODS: We used data...
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