Article

Polygenic Risk Modelling for Prediction of Epithelial Ovarian Cancer Risk

2020-12-02

Abstract excerpt

Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance over standard approaches of PRS construction. Here, we implemented computationally-efficient, penalized, logistic regression models (lasso, elastic net, stepwise) to individual level genotyp...

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Literature Corpus work: c0959225-bf25-5ed0-9fbe-4fa01096099a
DOI: 10.1101/2020.11.30.20219220

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